The two leaders will meet on March 5 after Prime Minister Netanyahu delivers an address to the annual AIPAC meeting in Washington.
Not surprisingly, the two issues at the front will be the continued bloodshed in Syria and the growing power of Iran.
Speaking at the opening of the weekly cabinet meeting on Sunday, Netanyahu said, "Our region is volatile and quickly changing in the North, South and East, including the atrocious massacre we are seeing in Syria against innocent civilians. All of these subjects will be raised at the meeting, but one issue will be central: the increasing power of Iran."
While we will discuss all of these issues, there is no doubt that one issue will be at the center of our talks, and that is, of course, the continued strengthening of Iran and its nuclear program.
Whoever needed it, received additional, biting proof in the form of the IAEA's latest report which proves that Israel's assessments were correct. i.e. that Iran is continuing to make rapid progress in its nuclear program, without let-up,while defying and grossly ignoring the decisions of the international community.
Netanyahu's comments came after the International Atomic Energy Agency released a report on Friday, which said that Iran has sharply stepped up its controversial uranium enrichment drive.
The IAEA report to member states showed Iran had carried out a significant expansion of activities at its main enrichment plant near the central city of Natanz, and also increased work at the Fordow underground facility.
Obama is also set to address the AIPAC conference where he is likely to refrain from criticizing Israel too much. And Netanyahu will probably praise Obama profusely during his address, knowing the political sentiments of his audience.
But behind closed doors, you might expect a rather tense meeting. Obama is dead set against Israel launching a strike against Iran while Israel's prime minister is probably leaning toward destroying as much of Iran's nuclear program that his military can reach. But this argument won't be settled now, so any disagreement is likely to be papered over when the meeting is finished.